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Frequently asked questions


Our mission is to connect everyone working tirelessly to accelerate the progress of GPCR druggability.

G-Protein Coupled Receptors (GPCR's), aka 7 Transmembrane Receptors (7TMRs) are the largest family of proteins with an amazing diversity in both receptor and the type of stimulus (ligand) they sense the cell’s surrounding environment.

GPCR's control a plethora of physiological processes that include development, sight, smell, taste, and are also involved in diseases such as hypertension, diabetes, and cancer.
 

GPCR's fulfill a plethora of pathophysiological roles and have druggable sites that are accessible at the cell surface among other reasons.
 
There are approximately 800 human genes that code for GPCR's of which half are olfactory (smell) receptors.
 

~ 110 of them are currently targeted by FDA approves drugs

~ 70  are being evaluated as potential novel targets
 

~ 600 GPCR's of which 400 are olfactory receptors.  Not all would be good drug targets, however, understanding their biology and potential pathophysiological function would help uncover a pool of untapped potential targets to explore.
 

1- Continued work to increase the number of GPCR structures and a better understanding of receptor pharmacology.

2- Better tools such as compounds and disease models to evaluate receptor function in health and disease. 

3- Establish more partnerships between key players in both the private and public spheres
 

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