G-Protein Coupled Receptors (GPCR's), aka 7 Transmembrane Receptors (7TMRs) are the largest family of proteins with an amazing diversity in both receptor and the type of stimulus (ligand) they sense the cell’s surrounding environment.
GPCR's control a plethora of physiological processes that include development, sight, smell, taste, and are also involved in diseases such as hypertension, diabetes, and cancer.
~ 110 of them are currently targeted by FDA approves drugs
~ 70 are being evaluated as potential novel targets
1- Continued work to increase the number of GPCR structures and a better understanding of receptor pharmacology.
2- Better tools such as compounds and disease models to evaluate receptor function in health and disease.
3- Establish more partnerships between key players in both the private and public spheres