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FR900359: nature’s weapon and treasure trove for basic and translational research
Friday, 9/17/2021 @ 1.00 PM - EST
- Dr. Evi Kostenis -
- The University of Bonn -
- Bonn, Germany -
Abstract
Natural products have been a rich source of compounds for basic research and drug discovery has given their exquisite specificity to interact with their cognate molecular targets. One such example is FR900359 (FR), a cyclic depsipeptide originally isolated from the ornamental plant Ardisia crenata. FR and its structurally close analog YM are highly selective inhibitors of Gq family proteins. Therefore, they offer the exciting perspective to interfere with Gq-dependent signaling in health and disease: in health to understand Gq contribution to complex signaling networks, in disease to treat pathologies caused by overactive Gq proteins. This talk will briefly introduce the fascinating molecule and provide an update on the gamut of attractive possibilities to utilize FR and its analogs for interfering with Gq-dependent signaling mechanisms.
About Dr. Evi Kostenis
pharmacist by training, Ph.D. in pharmacology, GPCR allosterism, POstdoc at the NIH with DR Jürgen Wess, molecular and cell biology, GPCR signal transduction; group leader at Aventis Pharma, cardiovascular disease group from 1999-2002; head of in vitro pharmacology at 7TM Pharma in Kopenhagen, Denmark, since 2006 full professor at the University of Bonn
Author list and affiliations
- Evi Kostenis, University of Bonn
Dr. Evi Kostenis on the web
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