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Molecular basis of adhesion GPCR activation
Friday, 09/17/2021 @ 2:00 PM - EST
- Dr. Demet Araç -
- The University of Chicago -
- Chicago, Illinois, USA -
Abstract
Adhesion G Protein-Coupled Receptors (GPCRs) are cell adhesion proteins that mediate cellular communication and play critical roles in embryonic and neural development. Their mechanisms of action remain poorly understood. In the past several years, three-dimensional structures of adhesion GPCRs and their ligands have been reported at atomic resolutions and revealed distinct protein folds and unique structural features. In this talk, we will discuss these structures which, together with structure-guided biochemical and functional analyses, provide hints for the mechanisms of trans-cellular communication at the synapse and other cell-cell contact sites.
About Dr. Demet Araç
Demet was an undergraduate at Bilkent University in Turkey, where she majored in Molecular Biology and Genetics. She moved to the University of Texas Southwestern Medical Center at Dallas to work with Dr. Jose Rizo-Rey as a graduate student to elucidate the mechanisms of neurotransmitter release. After finishing her graduate training, she joined Dr. Axel Brunger’s lab at Stanford University to study the structure and function of cell-adhesion proteins at the synapse. In 2013, Demet began her independent research career at the University of Chicago within the Department of Biochemistry and Molecular Biology.
Dr. Demet Araç on the web
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